Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis
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چکیده
منابع مشابه
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
BACKGROUND & AIMS Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have investigated the association between increased intestinal permeability and NASH. Our meta-analysis of this association investigates the underlying mechan...
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The liver lies at the intersection of multiple metabolic pathways and consequently plays a central role in lipid metabolism. Pathological disturbances in hepatic lipid metabolism are characteristic of chronic metabolic diseases, such as obesity-mediated insulin resistance, which can result in nonalcoholic fatty liver disease (NAFLD). Tissue damage induced in NAFLD activates and recruits liver-r...
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Nonalcoholic steatohepatitis (NASH), characterized by fatty infiltration of the liver, hepatocellular injury, and hepatic inflammation, is a major cause of liver failure. The pathogenesis of NASH is incompletely understood, but generally occurs in individuals with preexisting nonalcoholic fatty liver disease (NAFLD) or uncomplicated steatosis. Whereas most individuals with NAFLD will not develo...
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Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder of lipid metabolism that is associated with abnormally low serum levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B. It is an autosomal co-dominant disorder, and depending on zygosity, the clinical manifestations may vary from none to neurological, endocrine, hematological or liver dysfunction. Nonalcoholic...
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Hepatic drug metabolizing enzymes and transporters play a crucial role in determining the fate of drugs, and alterations in liver function can place individuals at greater risk for adverse drug reactions (ADRs). We have shown that nonalcoholic steatohepatitis (NASH) leads to changes in the expression and localization of enzymes and transporters responsible for the disposition of numerous drugs....
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2021
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2020.12.007